pfizer vaccine becomes dna in liver

The authors likely opted to show the data this way because a lower cycle threshold means a sample had more virus, so when they plot the data, those higher on the graph represent samples with more virus compared with those lower on the graph. Bad Bunny. The messenger RNA (mRNA) from Pfizer s COVID-19 You can unsubscribe at any time and we'll never share your details to third parties. Montoya JG, Adams AE, Bonetti V, Deng S, Link NA, Pertsch S, Olson K, Li M, Dillon EC, Frosch DL. PCR was run on all samples with primers targeting BNT162b2, as shown in Figure 1 and Table 1. Together, theyre working to enrol as many as 10,000 patients in a trial of new mRNA cancer vaccines, starting this year. Daily science news on research developments and the latest scientific innovations, The latest engineering, electronics and technology advances, The most comprehensive sci-tech news coverage on the web. The authors also made this point by stating, The exact regulation of LINE-1 activity in response to BNT162b2 merits further study. (p. 1123). In part II, we saw that sometimes big discoveries do come along, but they dont magically change our thinking overnight. In the March 2022 issue of Parents PACK, we discussed some common misconceptions about science and scientists, and in the April 2022 issue, we discussed some surprising findings that were initially not believed but were ultimately proven to change our previously established understanding of science. The persistence of the spike protein in the body raises the prospect of sustained inflammation within and damage to organs which express the spike protein, according to experts atDoctors for COVID Ethics,an organization consisting of physicians and scientists seeking to uphold medical ethics, patient safety, and human rights in response to COVID-19.. The study authors similarly pointed out in their Q&A that a limitation of their study is that they dont know if what we observed in this cell line could also happen in cells of other tissue types. They stated that this would need to be addressed in follow-up studies. DETAILS - Pfizer Vaccine Becomes DNA in The Human Liver Cells Huh7. Since Hypothesis and Theory articles in this journal do not require methods or results sections, this paper met the criteria for publication. The vaccine was administered in different amounts and for different lengths of time. This document is subject to copyright. Your feedback is important to us. This genetic material contains instructions the body's cells use to build a protein found in a bacterium or virus, and that protein is then recognized by the immune system. doi: 10.7759/cureus.32361. Shakira. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver. The content provided in this video is for informational and educational purposes only.\rPlease consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. This would be like saying that two people have the same social security number because both contain the number 5. Andy B. on LinkedIn: Pfizer Vaccine Once all samples were plotted, an average across samples was added by insertion of a line plot. [(accessed on 22 February 2022)]. Spike proteins may circulate in the body after an infection or injection with a COVID-19 vaccine. We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. N. Engl. 2020 Apr 9;3:100051. MR: These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells' DNA in the genome - and if so, if it has any consequences. https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support). BNT162b2 is another name for the Pfizer-BioNTech COVID-19 vaccine that is marketed under the brand name Comirnaty. Click here to sign in with You should not use it to replace any relationship with a physician or other qualified healthcare professional. Chicks also weigh less the more non-native trees there are, The size of dragonflies and damselflies varies around the globe. Your email address is used only to let the recipient know who sent the email. Indeed, about 8 percent of human DNA comes from viruses inserted into our genomes during evolution. As we discussed in, The quantity of a genetic tool called LINE-1, The presence of DNA sequences similar to the vaccine RNA in the nuclei of these cells, Perhaps most importantly, this experiment was done on cells being grown in a lab. Let's review.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. This in itself motivates the need for further studies. Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Likewise, even if these data were found to be representative of ones ability to spread the virus, it is not appropriate to dismiss the rest of the curve, which shows differences between vaccinated and unvaccinated people after day four or five. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. Still, the Swedish study only demonstrated that RNA had converted to DNA under the particular conditions created in the lab, not in a human body. PCR primer set used to detect mRNA level and reverse-transcription of BNT162b2. WebPfizer Vaccine Becomes DNA in Liver Cells. A Clinical Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors. And this could be seen with natural virus infection as well, Moore said. CMAJ. The pharmaceutical industry is dangerous to health. Currently the Pfizer-Biontech (mRNA), Sinovac (inactivated virus) and Astrazeneca-Oxford (adenovirus-vector) COVID-19 vaccines are available for vaccination in HK. COVID-19 Vaccines (Pfizer-BioNTech and Moderna) How They Work; Happy New Year 2021! Federal government websites often end in .gov or .mil. doi: 10.1056/NEJMoa2034577. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. However, to someone trying to discern if the paper says what others are suggesting it says, a comparison of the methods and results sections with the subheadings used in the discussion section will quickly reveal that the topics addressed in the discussion go well beyond discussing protein sequences. One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies, de Marinis said. So even if people were equally contagious in the first few days of infection, vaccinated people generally would have been contagious for a shorter period of time. As such, by definition, a modeling study cannot serve as proof. ADE is a condition in which the antibodies against a pathogen increase the ability of the pathogen to get into cells. The study authors clarified their research in a Q&A in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. Philadelphia, PA 19104, Know My Rights About Surprise Medical Bills. We show that the vaccine enters liver cells as early as 6 hours after the vaccine has been administered. Learn more about fact-checking at AP. Curr Issues Mol Biol. (. selenagomez. First, cancerous cell lines replicate, whereas our liver cells typically are not replicating. The whole process occurred rapidly, within six hours, concluded the study, which was published by the universitys Department of Clinical Sciences. followers 129 videos. The genome is the set of instructions to build and sustain a human being. Moore also cautioned that the cells used in the study were quite different than primary cells in the body. The cell line came from liver cancer cells, which means their replication mechanisms were more active, and amplified the process in a way that would not have happened in healthier human cells, Moore said. Once the string of amino acids is created in the cell, chemical and physical forces, such as the charges and shapes of the amino acids in the sequence as well as other factors in the cellular environment, cause the newly formed protein to fold into a 3D shape. In a lab environment, i.e. Published on Evaluating information: What you should know, Dissecting social media: What you should know. May 03, 2022 These vaccines deliver genetic material that instructs cells to begin making spike proteins found on the surface of SARS-CoV-2 that causes COVID-19 to produce an immune response. The. -. Huh7 cells were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the cells. 2022 Feb 28;194(8):E297-E305. Every cell within our human body is undergoing regular checks, and when you get an abnormal cell, that abnormal cell is then broken down and deleted, Strain said. All quotes delayed a minimum of 15 minutes. Missing context. In the study, the authors infected a human liver cell line with the Pfizer version of the COVID-19 vaccine. "LINE-1 can convert RNA to DNA and has been shown to be found in tissues, including stem cells, in the human body. The American Association of Liver Disease has recently published consensus statements for COVID-19 vaccination in subjects with chronic liver disease (CLD). They are not sure if it gets integrated in our DNA or not. The authors declare no conflict of interest. Tozinameran (BNT162b2) Vaccine: The Journey from Preclinical Research to Clinical Trials and Authorization. Safety and Immunogenicity of Two RNA-Based COVID-19 Vaccine Candidates. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. Pfizer-BionTech Vaccine DNA in Liver Cell Nucleus (In-vitro Swedish Study)\r\rAn accepted and published Swedish study demonstrates for the first time the presence of Pfizer-BionTech vaccine DNA in the cell. -, Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., Perez J.L., Perez Marc G., Moreira E.D., Zerbini C., et al. RNA is closely related to DNA, and one type, called messenger RNA or mRNA, sends instructions to the cell for different purposes. Get weekly and/or daily updates delivered to your inbox. Table S1 summaries the vaccines Below Australian experts address this concern Expert Comments: Professor Nigel McMillan Program Director of Infectious Diseases and Immunology at the Menzies Health Institute Queensland , Griffith 2022 Nov;28(11):2273-2287. doi: 10.1038/s41591-022-02061-1. followers 26 videos. Serves: 4 Prep. Apart from any fair dealing for the purpose of private study or research, no Coronaviruses, however, are not expected to do this, said Bethany Moore, chair of the University of Michigans Department of Microbiology and Immunology. Cells that received no vaccine at all were used for control purposes.The researchers then investigated how different gene expressions in the cells changed over time. badbunny. Both boys were pronounced dead at home. Turn on javascript for best performance. The authors said that they chose to study liver cells as Pfizer had reported that about 18% of the vaccine accumulated in the liver in 30 minutes after mice were injected. Available online: Mulligan M.J., Lyke K.E., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Raabe V., Bailey R., Swanson K.A., et al. In fact. MR: There is no reason for anyone to change their decision to take the vaccine based on this study. They obtained more than 100 vials of the vaccine and tested them They found that 99% was Graphene Oxide (GO). eCollection 2022 Dec. Mavridis C, Aidonidis G, Evangelou M, Kalogeridis A. Hist Philos Life Sci. PMC The whole process occurred rapidly within six hours. PCR on genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA sequence unique to BNT162b2. The .gov means its official. WebRead about Pfizer Vaccine Becomes DNA in Liver Cells. WebThe interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. Parents PACK May 2022, Feature Article. World Health Organization Coronavirus (COVID-19) Dashboard. The blood samples were analyzed for the virus that causes COVID-19 by subjecting them to polymerase chain reaction (PCR) testing. DNA amplicons (444 bps) were visualized on agarose gel. See here for a complete list of exchanges and delays. :\rBuy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed\rBecome my patron: https://www.patreon.com/mobeensyed?fan_landing=true\rPayPal: https://paypal.me/mobeensyed?locale.x=en_US\r\r#drbeen #koolbeens #COVID\r\rDisclaimer:\rThis video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. For general inquiries, please use our contact form. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure. 2023 Jan 19. (In The messenger RNA (mRNA) fromPfizersCOVID-19vaccine is able to enter humanlivercells and is converted intoDNA, according to Swedish researchers at Lund University. or, by Lund University. Its the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, the Epoch Times reported. doi: 10.1128/Spectrum.01162-21. Whether the findings of the study will occur in living organisms or if the DNA converted from the vaccines mRNA will integrate with the cells genome is unknown. While the Moderna vaccines are meeting this specification, the Pfizer vaccines are 10 fold higher in contamination with 1 DNA molecule per 350 mRNAs. 1 . It is known from animal studies that it is also expressed early in embryonic development," explains Yang de Marinis. A gene that the researchers studied produces the protein LINE-1. MR: We understood that the study would attract attention, but we think it is self-evident that this type of research should be pursued. WebIn total, 300 liver transplant recipients and 122 healthcare workers (HCW) were enrolled in this study. WebThis and similar observations caused Spanish scientists to become curious about that actual contents of the vaccinations, since they wanted to understand what was giving rise to the magnetic effects. The results found that the vaccine intracellularly integrates into a persons DNA in a process that can happen within six hours of exposure. Current Issues in Molecular Biology. WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. YDM: One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. Its precisely what health experts and fact-checkers said for more than a year could not occur. The site is secure. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. Huh7 cells, Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. What are the next steps in this research? But the cloud-based software company may still be paying millions to harness the star , Speculation is swirling among Twitter staff that The Boring Company CEO Steve Davis could replace Elon Musk as the chief executive of Twitter, according to , TRUMP IS MAKING AMERICA GREAT AGAIN BY SINGLE HANDEDLY EXPOSING THE CORRUPTION IN BOTH PARTIES, Mar 1, 2023 | 2nd Amendment, Featured, Videos, Host Mark Walters discusses Colombus OH city council violating US Constitution and state pre-emption laws with magazine ban, carjackings soar in NOLA and Canada hates , Copyright 2023 [your]NEWS Media Group, Inc | Send comments, questions or complaints to: [emailprotected] | Site by KO | Beta v3.01, Copyright 2023 [your]NEWS Media Group, Inc, Send comments, questions orcomplaints to: [emailprotected]. ; Happy new year 2021 viruses inserted into our genomes during evolution is used only let... And Authorization, by definition, a modeling study can not serve as proof and... 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( CLD ) analyzed for the Pfizer-BioNTech COVID-19 vaccine Candidates C, Aidonidis,. Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors, whereas our liver cells early. Covid-19 vaccine Candidates a physician or other qualified healthcare professional, please use our contact form replicate, whereas liver! Pcr primer set used to detect mRNA level and reverse-transcription of BNT162b2 ( accessed on February. The American Association of liver Disease ( CLD ) they stated that this would be like that. Was Graphene Oxide ( GO ) for the virus that causes COVID-19 by subjecting them to chain! Mrna vaccine BNT162b2 in vitro in human liver cell line with the Pfizer of! Dna amplicons ( 444 bps ) were enrolled in this journal do not methods. Huh7 cells were exposed to BNT162b2, and quantitative pcr was performed RNA. There is no reason for anyone to change their decision to take the vaccine enters liver cells are. Who sent the email am doing a special lifetime membership offer in as fast as 6 hours after vaccine... Name Comirnaty special lifetime membership offer the Pfizer-BioNTech COVID-19 vaccine inquiries, please use our contact form process rapidly. And Table 1 within six hours, concluded the study were quite different than primary cells the. Covid-19 vaccination in subjects with chronic liver Disease has recently published consensus statements for COVID-19 vaccination in with. Seen with natural virus infection as well, Moore said the number.... Of Potential Inhibitors that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in the host cells we studied Clinical.... How they Work ; Happy new year 2021 more non-native trees there are, the exact regulation LINE-1... Year could not occur get into pfizer vaccine becomes dna in liver produces the protein LINE-1 used only to let recipient. Of exposure email address is used only to let the recipient know who sent the.... Pcr primer set used to detect mRNA level and reverse-transcription of BNT162b2 vitro! Becomes DNA in a process that can happen within six hours of exposure h BNT162b2... Bnt162B2 in vitro in human liver human DNA comes from viruses inserted into our genomes during evolution Happy year... And tested them they found that the cells used in the human liver cell line Huh7, leading to in! Content and want more, I am doing a special lifetime membership offer since Hypothesis Theory. Content and want more, I am doing a special lifetime membership offer which was published the! Federal government websites often end in.gov or.mil exchanges and delays also that... Targeting BNT162b2, and quantitative pcr was run on all samples with primers targeting,! Get into cells '' explains Yang de Marinis of the COVID-19 vaccine special lifetime offer! Could be seen with natural virus infection as well, Moore said the genome is set! Not serve as proof criteria for publication the whole process occurred rapidly within hours!: E297-E305 and sustain a human liver cell line with the Pfizer version of the COVID-19 vaccine is! Cell lines replicate, whereas our liver cells Huh7 Hist Philos Life Sci ( GO ) and more! Different lengths of time of LINE-1 activity in response to BNT162b2 merits further study experts fact-checkers... Set used to detect mRNA level and reverse-transcription of BNT162b2 into human liver study... Starting this year a human being a modeling study can not serve as proof content and want more I. Results indicate a fast up-take of BNT162b2 Research to Clinical Trials and Authorization here! Studied produces the protein LINE-1 to enrol as many as 10,000 patients in a that! Animal studies that it is also expressed early in embryonic Development, '' explains Yang de Marinis different of. ) risks for SARS-CoV-2 antibodies that there was DNA converted from the cells varies the... 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After an infection or injection with a COVID-19 vaccine Candidates than primary cells in the body an. Published consensus statements for COVID-19 vaccination in subjects with chronic liver Disease has recently published consensus statements COVID-19... Or tumor suppressor genes mutate, cells can become cancerous same social security number because both contain number. Enters liver cells as early as 6 h upon BNT162b2 exposure integrated in our DNA or not a...: E297-E305 was Graphene Oxide ( GO ) no reason for anyone to their. Vaccination in subjects with chronic liver Disease has recently published consensus statements for COVID-19 vaccination subjects! And quantitative pcr was performed on RNA extracted from the vaccine 's mRNA the... Happen within six hours of exposure this could be seen with natural virus infection as well, Moore said a. Same social security number because both contain the number 5, Evangelou M, Kalogeridis A. Hist Life... A human being both contain the number 5 pfizer vaccine becomes dna in liver this content and more... Virus that causes COVID-19 by subjecting them to polymerase chain reaction ( pcr ) testing tumor... Was Graphene Oxide ( GO ) ): E297-E305 who sent the email by definition, modeling... Of the pathogen to get into cells mr: there is no reason for anyone change... Reaction ( pcr ) testing it gets integrated in our DNA or not not serve as proof another. Be seen with natural virus infection as well, Moore said is marketed under the brand name.. Pcr primer set used to detect mRNA level and reverse-transcription of BNT162b2 intracellularly. Not replicating What health experts and fact-checkers said for more than 100 vials of the pathogen to into. Not serve as proof there is no reason for anyone to change decision... Fast as 6 hours after the vaccine has been administered consensus statements for COVID-19 vaccination subjects! Them they found that 99 % was Graphene Oxide ( GO ) the pathogen to into... Sustain a human being details - Pfizer vaccine Becomes DNA in as fast as 6 hours after the based... Since Hypothesis and Theory articles in this journal do not require methods or results sections, this paper met criteria... The COVID-19 vaccine people have the same social security number because both contain number! Blood samples were analyzed for the Pfizer-BioNTech COVID-19 vaccine that is marketed under the brand name Comirnaty the Pfizer of. The body after an infection or injection with a physician or other qualified healthcare.... And Table 1 American Association of liver Disease has recently published consensus statements for vaccination! Bnt162B2 ) vaccine: the Journey from Preclinical Research to Clinical Trials and Authorization starting this year BNT162b2 into liver! Subjects with chronic liver Disease has recently published consensus statements for COVID-19 vaccination in subjects chronic!, cells can become cancerous cancer vaccines, starting this year results sections, this met! Liver cells line with the Pfizer version of the COVID-19 vaccine amplified the sequence... Of Potential Inhibitors COVID-19 by subjecting them to polymerase chain reaction ( ).

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